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Particularly among the elderly, those with untreated hearing loss are less likely to participate in social activities and more likely to report levels of depression and anxiety (Bess et al., The primary cellular basis for ototoxic hearing loss is the death of sensory hair cells within the cochlea

Iron oxide (Fe 3 O 4 ) NPs produce toxic heat effects and induce ferroptosis via ACSBG1, an acyl-CoA synthetase that acts as a key pro-ferroptotic factor in this tumor-specific process (170)